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Because expression of the direct targets is induced just after Gcm starts being expressed (stage 10), we expect them to be enriched in the expression profiling data relative to the early stages.
Finally, because expression of the CYP2E1 gene is very high in tumor tissues but low in many normal tissues, GA could therefore produce tissue-specific proteasome inhibition and tumor-specific toxicity, with clinical significance for designing novel strategies for cancer treatment.
Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.
The above is an interesting observation because expression of the K-RasV12 oncogene was achieved in ∼8% of the cells of the thymus (quantified in scanned photographs; see example in Supplementary Fig. S2).
Because expression of the GmGT-2A and GmGT-2B genes can be induced under drought and cold treatments, we investigated if the performance of their transgenic plants was altered under these stresses.
Because expression of the human immunodeficiency virus-1 (HIV-1) gag gene in cultured cells promotes formation of PrPSc in the cell culture models of prion disease [47], we assessed whether HIV-1 Gag influences in vitro amplification of PrPSc.
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Because expression of SrcDN alters the shape of MCF7 cells, immunofluorescence confocal analyses showed concentrated focal adhesion proteins.
Our data are consistent with this work, because expression of hSulf2 had the opposite phenotype in decreasing tumor cell growth.
However, this possibility appears unlikely because expression of rpr from the GMR-promoter is sufficient to induce apoptosis.
As described above, because expression of Dp53 induces expression of the apoptotic gene hid, we examined whether GMR- p21 can modulate GMR- Dp53-induced expression of hid.
Because expression of L126Z hSOD1 is above the threshold to induce disease, we are looking only for an augmentation of toxicity.
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