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Furthermore, in the sensitivity analyses, the romiplostim dose was set as two vials per dose instead of one vial as set in the base case analysis because even slight changes in body weight would lead to changes in the number of vials if the remainder of the drug was assumed to be discarded.
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Although we have no criteria available to judge the value of the minimally important difference (MID), but logically even slight changes in self-efficacy can have tremendous value because feelings of competency can have greatly impact a patients' mental status.
Significant savings are possible with even slight changes in rates.
Even slight changes in the cells that make the proteins can change the drug's properties.
"They have semipermeable skin, so even slight changes in rainfall can really affect them.
As the article points out, even slight changes to a biologic drug can change its properties entirely.
Even slight changes in a biologic might, for instance, cause a patient to have an immune reaction to a drug.
Even slight changes in the shape of a protein may affect how well a particular antibody sticks to it.
Typically, metabolic process was highly susceptible to even slight changes in pH.
Even slight changes may have significant impact on the quality of the final products [18, 19].
But even slight changes can result in big headaches for designers trying to achieve a certain effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com