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This result indicated the importance of codelivery of drug molecules in time and space because different rate of cellular uptake and release site of drugs may hamper the therapeutic effect of combinatorial drug treatment.
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Nonetheless, recent simulation work suggests the limited usefulness of these metrics alone in diagnosing PNC because different rates of niche evolution (different degrees of niche conservatism) can yield a similar phylogenetic signal, while a low phylogenetic signal can also emerge under strong niche conservatism (Revell et al., 2008; Ackerly, 2009).
Dosages of first-line anti-tubercular drugs in children have been increased in 2009 by WHO, because several pharmacokinetic studies have shown that infants and young children have lower peak serum levels than adolescents and adults, because of a different rate of metabolism, clearance and distribution of drugs [ 98, 99].
Because this group experiences a systematically different rate of alcohol-related harm compared with the general population, correspondingly different outcomes in our comparisons are expected, even if the SHeS accurately represents its target population.
Linkage probabilities between older and younger patients differ because of different rates of changes of address [ 26].
It has been proposed that because of different rates of basal recognition of letters, a suppression score (percentage of correctly recognized letters at 100 ms SOA divided by maximum percentage of correctly recognized letters at any other SOA) would be a more reliable measure of MSPA [7, 8].
It suggests that the difference between two types of seedlings in the early stage in S. aralocaspica arose because of different rates of emergence time rather than for other reasons.
Because of different rates of lymph node dissection among the two groups, an alternate version of the model that excluded all patients with lymph node dissection was also evaluated.
The Mogollon culture has been divided into various developmental periods, though consensus is lacking because of incomplete evidence and because of the different rates of development across the immense geographic area these people inhabited.
There are no specific "overweight" and "obese" categories for children because they have different rates of growth and development.
Although simvastatin proved safe in the study, Dr. Collins said that it was difficult to extrapolate the findings to other statin drugs because each may have different rates of side effects.
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