Sentence examples for because activation of the from inspiring English sources

But, except the activation of c-Jun (taof JUN)), the predicted activity of the RAS/RAF/MAPK pathway could not be identified, maybe because activation of the MAPK pathways is very fast and transiently regulated via phosphorylation and dephosphorylation.

Mice expressing Magneto spent far more time in the magnetised areas than mice that did not, because activation of the protein caused the striatal neurons expressing it to release dopamine, so that the mice found being in those areas rewarding.

Because activation of the MAPK pathway is documented to promote DP differentiation in the absence of allelic exclusion, we characterized the properties of Vbeta chromatin within DP thymocytes generated by a constitutively active Raf1 (Raf-CAAX) transgene.

Because activation of the PKC pathway may increase endothelial permeability [25] and because HBP is shown to stimulate PKC activity [26], we tested the hypothesis that HBP increases permeability via the PKC pathway.

Because activation of the trigeminal nucleus is essential during the pain phase of a migraine attack, we decided to study the effect of TRPV1 antagonism in this anatomical region.

This would be expected simply because activation of the myosin II motor domain by phosphorylation of the RLC is expected to be required for contraction of the furrow.

However, until now, these observations have been considered to be consequences of disease pathology because activation of microglia, the resident immune cells of the brain, can result from neurodegeneration [39].

Because activation of AhR is the initial cellular effect of BP, we next analysed whether this receptor plays a role in the enhancement of CD95-mediated apoptosis.

The possibility that mice lacking mu-opioid receptors exhibit increased activity in PFC-striatal circuits is less convincing because activation of mu-opioid receptors in the PFC inhibits GABA interneurons that synapse on PFC projections [39].

This result is not unexpected, however, because activation of NOX2 requires not only the signaling pathway described here, but also p47phox phosphorylation at additional sites and the concomitant activation of both rac1 and phospholipase A2.

The molecular mechanism proposed applies not only for the zebrafish because activation of TNFRSF1A also promoted apoptosis and caspase-2 and P53 activation in human endothelial cells following TNFα treatment.