It is based on a piece of evolutionary theory called the founder effect, which shows how the isolation of small populations from larger ones can accelerate evolutionary change, because a small population's average characteristics are likely to differ from those of the larger group from which it is drawn.
However, cessation of taking imatinib may result in disease relapse, because a small population of leukemic cells can survive imatinib treatment and retain capacity to self-renew [ 5].
"A lot of stuff has been published, but not all of it is of the same quality, even though it's in the peer-reviewed literature, either because of a small population study or inadequate controls," he says.
This theory provides a rationale to explain the failure of many currently used antitumoral strategies, because just a small population of CSCs resistant to the therapy would be enough to maintain the whole tumour mass (Etzioni et al, 2003; Chabner and Roberts, 2005; Huff et al, 2006).
Because we simulated a small population where chance events can have major effects, we used a stochastic transmission model.
That being said, the impact of these data on the estimate may not be substantial because this is a small population.
The prevention of homicide recidivism by people who have committed a homicide offence and are diagnosed with schizophrenia might be feasible because they are a small population with identified treatment needs.
The Swedish team used live donors because, having a smaller population, they could not rely on a ready supply of cadavers.
"We're the last ones anyone takes seriously, because we're such a small population," said Jessie Parker, of Perry, Me., as she waited for the caucus to start.
Other techniques viewed 7SK RNA as an average structure of these different populated states, and because Tat binding only induced a small population shift between the substates compared to HIV-1 or HIV-2 TAR RNAs, it appears that little overall conformational changes occurred in 7SK RNA upon Tat binding.
"It's very clear that it's a small population, because there are many biologists working in the area, and by now it would have otherwise been a known species," he said.
