Because it was reported in a previous work that experimentally evoked LTP is able to occlude any further learning even for >10 days after potentiation disappearance [14], we also tested whether PKMζ inhibition reverses the effects of HFS-induced LTP before the eyeblink conditioning test.
We feel that it is not unreasonable to apply the implied relative risks from risk models to a cross-sectional study, albeit with a recalibration, because previous work has found breast cancer risk factors to have a similar magnitudes in case control studies as for cohorts (see, e.g., [ 30]).
We started by analysing the role of PI3K activity as a VPA target, because our previous work had shown that both VPA treatment and pharmacological inhibition of PI3K activity (using LY294006) (Xu et al., 2007) mediated a reduction in Dictyostelium phosphoinositide levels and a reduction of glutamate release in isolated rat hippocampal cells.
You can, however, do it to monkeys, and the researchers did.Unhappy minds in unhealthy bodiesDr Tung and Dr Gilad took 49 middle-ranking female macaques (females were chosen because a lot of previous work on animal hierarchies has been done on female macaques) and split them into groups of four or five.
This is an important development because most previous work on ERβ has been at the mRNA level.
In the present study, we coinjected oocytes with KCNQ1 and KCNE1 transcripts at a 1 1 ratio because previous work, from our lab (Li et al., 2011) and others (Nakajo et al., 2010), demonstrated that this ratio is sufficient to saturate the functional effects of KCNE1 on KCNQ1.
Because this previous work was not a systematic review and because our aim was not to carefully look for all articles exhibiting internal inconsistencies between their results sections and conclusions, both articles represent examples of internal inconsistencies.
Western Scrub-Jays (Aphelocoma californica) are an excellent model for testing the mismatch between mtDNA and nuclear markers across a hybrid zone predicted by Haldane's Rule because previous work documented a zone of secondary contact and hybridization between two divergent lineages.
This is a little more mysterious because previous work with this TF in other fungi indicates a role in osmotic / oxidative stress responses via the SakA MAP kinase.
We chose not to cross with an albino strain because previous work has shown that the allele that confers albinism is itself associated with reduced fear conditionability (Ponder et al. 2008), and selecting for such a mechanism of fear resilience would not have translational relevance for non-albino populations.
