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Because this previous model is limited to cell gradient sensing at steady state in one-dimension (1-D), which is fundamentally different from the dynamic cell migration process, the modeling results could not be directly compared with experimental cell migration data.
Briefly, because the previous model was developed for the utilization of multiple five- and six-carbon sugars, all of the carbon-source utilization reactions besides the glucose utilization reaction were removed; glucose was assumed to be actively uptaken by the phosphoenolpyruvate sugar transferase system.
Because the AUC value of our prediction model for new samples from the same population is expected to be below the calculated apparent AUC (especially because of the previous model selection incorporated in the LASSO approach), we applied bootstrap resampling as described in Steyerberg [39] to calculate an optimism-corrected AUC-value.
The first aspect is important because many previous models were trained either on a small number of high-resolution binding regions (Barash et al., 2003; Zhou and Liu, 2004) or on high-throughput in vivo data (Sharon et al., 2008; Siddharthan, 2010), both of which are noisy, have low resolution and may reflect both direct and indirect DNA binding of the tested TFs (Gordân et al., 2009).
This is unexpected because most previous models predict that older age groups would bear the brunt of a rise in shingles, but this younger population would be less likely to develop lasting complications of shingles.
Because the failure of the previous model tested boiled down to an overestimation of the force measured in muscles during large, smooth, elongations, it seemed natural to us to retrofit that model with a variable attenuator.
This may be a particularly useful starting point in international EM, because previous models for assessing emergency care systems in foreign countries have received criticisms of oversimplification and implied categorization.
Gender was also included as a predictor in the model, because a previous study found differences in satisfaction between men and women [ 13].
This effect on neutrophilia in particular could be due to the LPS component of the model because a previous comparison showed attenuated BAL neutrophilia with chronic compared with acute LPS challenge which was believed to be due to the resolution phase of acute inflammation preventing further neutrophil recruitment [ 38].
