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Forelimbs and skulls became modified in advance of hind limbs, adapted for supporting the head and front of the body out of the water, probably in connection with air breathing.
…seven genera of Ganoid fishes…these anomalous forms may be called living fossils … (Darwin 1859, p. 106) Understanding the genetic mechanisms by which doubled genomes became modified in ancient teleosts requires the study of a surviving lineage that diverged from the teleost lineage before the TGD.
Two evolutionary scenarios can account for this: (1), an acrothoracican-type ancestor has led equally to both the Thoracica and the Rhizocephala; (2) a thoracican-like ancestor of both lineages became modified in both the Acrothoracica and the Rhizocephala, while its morphology remains reflected in the most plesiomorphic extant thoracicans such as the Iblomorpha [ 39].
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As environmental conditions change, inherently determined responses also become modified in order to ensure continuation of the species.
The carbohydrate residues of lysosomal enzymes become modified in the cis-Golgi by the addition of certain phosphate groups.
Beetles that live in nests of ants and in nests of termites have become modified in form because certain structures that are no longer needed have degenerated (e.g., wings, wing covers); some have almost lost the power of locomotion.
Our in silico, cellular, and molecular approaches demonstrate that the canonical autophagy pathway has become modified in P. falciparum.
If these assembly pathways become modified in evolution, the identities of the assembly intermediates will change, potentially increasing their susceptibility to misassembly or aggregation.
In contrast to naive bicoid mRNA, endogenous bicoid mRNA is transported into the oocyte after being transcribed in neighbouring nurse cells where it also becomes modified in presence of the protein Exuperantia.
In conclusion, in an acute phase, the carbohydrate structure of fibrinogen becomes modified in such a way as to increase the proteins concentration and the rate of fibrin polymerisation and clot formation, helping to maintain haemostasis.
However, our results show clearly that the bulk ER membrane is not the site of lipidation, thus if the omegasome arises from the ER, it must become modified in some way to be active for LC3 lipidation.
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