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Interestingly, the Me1007 cell line, resistant to SMAC-mimetic/TRAIL, became extremely sensitive to the combination of SMAC-mimetics and Bortezomib, the latter widely used in cancer therapy.
In particular, p̄ became extremely sensitive to the rate of transcriptional activation induced by tamoxifen-receptor complexes (k sr,i ), and to the total concentration of estrogen receptor (ERt).
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Above a critical UI value, the flame detaches from the inlet and Lf becomes extremely sensitive to UI until, for sufficiently high UI, the sensitivity decreases and Lf corresponds to the location expected from a purely autoignition stabilised flame.
Those who inject cocaine – the favoured drug in this area – become extremely sensitive to noise while high.
As nominal interest rates on long-term bonds become low, their market prices become extremely sensitive to tiny changes in open market interest rates.
A common change that occurs when prostate cells turn cancerous is that they become extremely sensitive to testosterone so much so that late-stage prostate cancer is often referred to as being "castration-resistant", because even that drastic testosterone-reducing treatment cannot halt it.
At the critical value ξ crit = − 1 / 27 the derivative ∂ n / ∂ δ diverges and thus the response of the parametric amplifier becomes extremely sensitive to small changes.
From the perspective of a university teacher who has become extremely sensitive to any form of FCM, in terms of the integration of teaching and technology, TAL has gone much farther than most universities including the one the author is working with.
Systems of disparate nature, when subjected to excessive loads, approach a critical state at which they become extremely sensitive to perturbations that can be efficiently propagated under these conditions [61], [62].
Furthermore, these cells exhibit an increased dependence on EGFR signaling for proliferation and survival and they become extremely sensitive to gefitinib (Nicholson et al, 2002).
Breast cancer cells that have grown under long-term estrogen deprivation (LTED) become extremely sensitive to estrogen (Masamura et al. 1995, Santen et al. 2005).
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CEO of Professional Science Editing for Scientists @ prosciediting.com