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Intriguingly, studies of the kinetics of antigen-driven BCR cluster growth in WT and SAP97-deficient IgG-BCR-expressing B cells showed that SAP97's function was not required in early BCR signaling when oligomerization and initial clustering occurred (before 5 min), but became essential for efficient clustering subsequently (unpublished observations from Xu and Liu).
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These lessons, he said, became essential for later projects.
Thus, personalized medicine, i.e. knowing the molecular signature of the tumor to be treated, has become essential for optimal and efficient treatment of cancers.
Creativity and critical capacity become essential for successful lifelong learning.
Evolutionary design principles may become essential for designing nanodevices.
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