Sentence examples for became deleterious from inspiring English sources
However, after Cit+ was refined by further mutations, this potentiating gltA mutation became deleterious to fitness.
Under subsaturating conditions, however, the R1039A mutant became deleterious, revealing a role of R1039 in substrate binding.
Once cells became strong citrate utilizers, the initial gltA mutation became deleterious driving the evolution of a diversity of secondary mutations to compensate for its cost.
Among women, consumption of 24 g/day alcohol was most protective (0.60 [0.52–0.69]) and became deleterious at about 50 g/day alcohol (1.02 [0.83–1.02]).
Compared with lifetime abstainers, the relative risk (RR) for type 2 diabetes among men was most protective when consuming 22 g/day alcohol (RR 0.87 [95% CI 0.76 1.00]) and became deleterious at just over 60 g/day alcohol (1.01 [0.71.0144]).
Two cellular mechanisms normally beneficial to the organism when acting independently, one involved in tissue nourishing and the other in healing, i.e., erythrogenesis and scar formation (or foreign body encapsulation ) respectively, became deleterious by creating the capsular vaso-mimicry when they coincided in the ectopically implanted tumor.
Interestingly, surgery did not become deleterious, whereas medical management improved.
However, during septic shock, immunothrombosis may also become deleterious, contributing to major tissue insult and excessive coagulation activation [11 13].
On the other hand, thrombin can become deleterious if ongoing activation of the coagulation, owing to defective natural anticoagulants, leads to excessive thrombin formation.
Further studies need to confirm these data and to evaluate more precisely at which time point of the growth period and from which amount a localized peripheral growth plate injury may become deleterious for further longitudinal growth.
The concept of a Darwinian-evolutionary basis for the development of age-related diseases in principle postulates that genetic traits that are beneficial in younger years to allow for successful reproduction may become deleterious in the elderly, i.e. when selective pressure does not seem to be effective anymore.
