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However, taken the next previous reports; ER resident proteins were the predominant targets of the H2O2-induced oxidative stress [23], and protein folding in ER became defective under the H2O2-induced oxidative stress condition [24], a possible explanation for this finding is that periostin supports protein folding of Notch1 precursor in the ER under the stress condition.
We cannot exclude that the stroma protective function towards anoikis in metastasis became defective, Beclin-1 persisting elevated.
Uric acid deposits can also be lysed by the enzyme uricase, the coding gene for which became defective in humans in the Miocene because of an evolutionary mutation.
Many of the integrated retroviruses (proviruses) became defective due to accumulation of nonsense mutations, large internal deletions, or reduction to so-called solitary LTRs after homologous recombination within a provirus [for reviews, see [ 1- 4]].
This is essential not least because if a mains water holding component within that boiler became defective and thus enters the Heating side of the boiler there would be potential for all sorts of problems with floods in the loft area and much more.
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In this paper, we try to explain the maintenance of cooperation in multiplex networks with limited and partible resources of agents: defection brings larger short-term benefit and cooperative agents may become defective because of the unaffordable costs of cooperative behaviors that are performed in multiple layers simultaneously.
The system may become defective at any point of time when it is in operation.
Cancer cells are well known to be the metabolically streamlined cells in which many metabolic pathways become defective in comparison to their normal cell counterparts.
If you fail to inform the police or Home Office when you lose your card, or if it becomes defective, you face a fine of up to £1,000.
Tissue engineering aims to regenerate, repair or replace organs or tissues which have become defective due to trauma, disease or age related degeneration.
However, the GPS capability may become defective or the environment may be GPS-denied, and an additional safety aid is therefore required for the automatic landing phase that is independent of GPS data.
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