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A lack of venture capital in the state became a significant problem with the early industry.
In large part due to the rapid population growth, cholera became a significant problem.
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Childhood obesity has become a significant problem in many countries.
The Information Technology Association of America, a trade group, said last week that it would help create the Coalition on Online Identity Theft, composed of Internet retailers and security companies allied against what has become a significant problem both online and off.
Back to the top In the universal credit white paper (pdf), the government argues: "Welfare dependency has become a significant problem in Britain with a huge social and economic cost".
This means it pays higher rates, but it is also not running into what has become a significant problem for political advertisers this year: getting bumped by someone offering to pay a higher price.
They could be ideal for storing wines that are inclined to be high in alkyl-methoxypyrazines but will be drunk relatively soon after purchase, before oxidation can become a significant problem.
Fungal infections have become a significant problem for immunosuppressed patients.
Excess water production has become a significant problem for oil field operations as reservoirs mature.
The growing demand for colonoscopies and inappropriate colonoscopies have become a significant problem for health care.
As semi-submersibles increase in size, the effect of vortex-induced motions (VIMs) becomes a significant problem in their design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com