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Infections caused by multi-resistant germs became a severe issue due to the widespread application of antibiotics[25, 26].
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Don't wait until it becomes a severe issue and then finding yourself using, "Well, this has been going on for some time", as a defensive ploy in your favor.
Online games are a mainstream recreation among internet users, and IGA, which broadly refers to the inability to stop playing, has become a severe social issue [ 1, 5].
Given the rapid increase of HIV/AIDS cases in China, HHV-8 could become a severe public health issue in the future.
Money has become a serious issue.
That is, they know it's a severe issue but it seems almost hopeless.
But, given that these parties are competing with the far right for the same disenchanted voters, their humanism on these issues has become a severe political handicap, which may explain why the extreme right has lately been more successful electorally.
Obesity has become a severe health problem in the world.
At 50%, it becomes a "severe burden".
It became a political issue.
"So safety became a paramount issue".
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