After baseline metabolic and hemodynamic measurements, all animals underwent rapid right ventricular pacing using a customized pacemaker at 240 beats/ minute.
The mean respiratory rate was 31.4 cycles/ minute (± 8.18), the average cardiac pulse was 103.6 beats/minute (± 23.14).
In all animals the heart rate decreased to an average of 180 beats/minute during 90 minutes after the introduction of the intracerebroventricular two-component gel.
Changes in vital sign parameters occurred with 61% of patients experiencing increases in standing pulse rates and 32% experiencing increases in supine pulse rates above clinically important limits (increase ≥ 15 beats/minute and value ≥ 100 beats/minute).
A high heart rate was defined as a heart rate >100 beats/minute.
Her BP was 112/60 mmHg, heart rate 102 beats/minute, body temperature 36.7°C, and her pupils were 2.5 mm in diameter, equal, and reactive.
Her BP was 161/76 mmHg and heart rate 75 beats/minute before induction of general anesthesia, which was induced with propofol, remifentanil, and rocuronium.
The constant ω 0 is an angular frequency ω 0=(2π/60)×H R where H R is an average heart rate in beats/minute.
On admission, her body weight was 61 kg, height 1.54 m, blood pressure (BP) 106/64 mmHg, and heart rate 78 beats/minute.
Her vital signs were: body temperature, 36 °C; pulse rate, 66 beats/minute; respiratory rate, 20 breaths/minute; blood pressure, 89/44 mmHg.
The heart rate was elevated at 115 ± 29 beats/minute.
