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The fragment-based conformation sampling method (e.g. FARNA) bears shortcomings that the limited size of a fragment library makes it infeasible to represent all possible conformations well.
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I have shortcomings.
The analysis does have shortcomings.
Does it have shortcomings?
But citation metrics have shortcomings.
CRP does have shortcomings.
It was always wonderful to see Jo in a bright dress, bringing her ferocious intelligence to bear on the shortcomings of world leaders.
Previously used by private tutor Isaac Fleming in 1878, it was a building whose central urban position was, Taylor (1988) said, a "major asset, and possibly the only one"; Headmaster Bryant "bore its numerous shortcomings, its bricked ambience and grasslessness".
Yet as commander-in-chief, he bears responsibility for the military shortcomings if, as some suspect, North Korea torpedoed the Cheonan from a semi-submersible vessel and got away with it.If that is indeed what happened, many will wonder what lies behind North Korea's aggression.
The BH3 peptides and the BH3 mimetics both bear an intrinsic shortcoming in that they inhibit the BCL-2 family proteins not only in cancer cells but also in normal cells as they cannot distinguish cancerous from normal cells.
It bears superficial resemblance to antisense, which despite shortcomings has advanced several drug candidates to the clinic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com