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Furthermore, the tripeptide that comprises the putative 50s loop of ISP1 (HQT) has no conservation with ecotin (LHR), whereas ISP2 (VYR) bears conserved substitutions in those positions.
The intracellular domain of CED-1 bears conserved binding sites for SH2 and PTB domains (Zhou et al., 2001b).
An early indication that V3 bears conserved structural elements allowing the broad cross-reactivity of V3 Abs directed to the crown of the V3 loop came from data showing that V3 participates in the binding of gp120 to the cell surface coreceptors CCR5 or CXCR4 and in determining virus tropism (Shioda et al., 1991, Shioda et al., 1992, Trkola et al., 1996, Hill et al., 1997).
Similar(57)
As with microRNAs, the conservation of snoRNAs among species suggests that they bear conserved biological functions.
capA, capA2, capB and capC, did not bear conserved domains.
Rather, they insert between host dinucleotide AT in the vast majority of cases, and bear conserved TC and CTRR nucleotides at their 5′ and 3′ terminal ends, respectively.
INTS2, MET and other members of the DCUN1 (DCUN1D4, DCUN1D4) and Dll gene families (Dll3) were among our list of IPed PUM mRNAs targets, whereas SDAD1 and VEGFA were not among the IPed messages, though they bear a conserved PUF binding motif.
Ub and Ub-like proteins bear a conserved diglycine motif at their carboxyl termini for isopeptide linkage to conjugated proteins.
C2H2 Zn fingers bear a conserved #-X-C-X 1-5 -C-X3- -X5- -X2-H-X 3-6 -[H/C] residues pattern where X represent any amino acid, and numbers in brackets indicate the number of residues.
The solution structures of chagasin and of Leishmania mexicana ICP determined by NMR showed that the molecule has an Ig-like fold and three exposed loop regions, which bear evolutionarily conserved residues, located at one end of the molecule [6,7].
The first of these helices bears two absolutely conserved positively charged residues (RxxR signature), while the second bears the W-TIP motif.
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