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Both seven-membered azacycle scaffolds bearing suitable functional groups, which can easily be modified by means of standard synthetic chemistry, serve as non-peptidic heterocyclic core structures for the further design and synthesis of aspartic protease inhibitors.
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Conventional hydrogen bonds [12], D − H∙∙∙A, are reliably formed between molecules with suitable functional groups that can serve as H-bond donors (D) and acceptors (A).
Detrimental effects can, however, be avoided by using suitable functional groups in the side chains, acting as internal plasticizers without being sensitizers for the photobleaching process.
However, chemical modification of the target can impact binding and requires suitable functional groups for conjugation.
These two reactions can occur multiple times [ 154], if suitable functional groups are available in the drug structure.
The activation of the aromatic ring is usually achieved by suitable functional groups with a M effect like the carbonyl, carboxyl, cyano, and nitro group [ 32].
Moreover, rice straw contains suitable functional group for effective adsorption capacity (Gao 2008).
Glucuronidation involves the conjugation of a suitable functional group present on a variety of structurally unrelated substrates with glucuronic acid and has an important cytoprotective role.
The complexation of noble metal chloro complexes with thiacalix[4]arene derivatives bearing or not bearing functional groups was studied by liquid liquid extraction.
Monodisperse magnetic nanoparticles (MNPs) were synthesized by thermal decomposition of iron-oleate and functionalized with silanes bearing various functional groups such as amino group (NH2), short-chain poly ethylene glycol) (PEG), and carboxylic group (COOH).
In this study, monodisperse MNPs (Fe3O4) were synthesized by iron-oleate thermal decomposition method and functionalized with silanes bearing different functional groups such as NH2, short-chain PEG, and COOH.
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