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As mentioned previously, we had identified a number of somatic mutations in different domains of PXN in NSCLC tumor tissues at the rate of 9.4% samples bearing mutation and 12.1% having PXN gene amplification.
A pUC18 plasmid containing nucleotide 2431 1990 of HBV (Genotype D, Genebank accession number: U95551.1), or the same plasmid bearing mutation generated by site-directed mutagenesis, was used for expressing HBV envelope proteins under the control of endogenous HBV promoter.
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The groups that generated clear signatures corresponded to the functional domains [ 69] mutated: patients bearing a mutation within the DBD (exons 5,6) and patients bearing mutations within the transactivation domain (TAD, intron 4,5, exon 3).
These findings implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53.
Both papers show that fruitflies bearing mutations in the fly version of PINK1 display degeneration of flight muscles and defective sperm formation.
Kan, R. et al. Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Strains bearing mutations in the CIN genes are approximately tenfold more sensitive than wild type to both benomyl and to the related antimicrotubule drug, nocodazole.
(a) Basal ROS levels in 3 healthy control cell lines (C1 to C3) and 7 patient cell lines (P1 to P7) bearing mutations in different nuclear encoded Complex I subunits.
Indeed, for Patients 2 and 3, we could detect small cell populations bearing mutations associated with the resistant subclone within the pre-treatment cells, but not in peripheral blood mononuclear cell (PBMC) from normal adult donors (Fig. 3d).
Receptors bearing mutations in any of the last three residues fail to interact with NSF.
Here, we generated for the first time transgene-free iPSCs from fibroblasts of five XP patients bearing mutations in XPA, XPB, XPC, XPG, and XPV genes, respectively.
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