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Some of the more recent ones, though, are traditionally flat, rectangular canvases bearing basic two-tone, vertical-stripe compositions.
The derivatives bearing basic amino side chain showed an improved antitumor activity.
Moreover, water-soluble substrates, water-containing substrates, and substrates bearing basic nitrogen atoms and free hydroxy groups and others can be used in aqueous Mukaiyama aldol reactions.
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Novel O6-substituted guanine analogues have been synthesized, bearing acidic, basic and hydrogen bonding functional groups.
Compounds bearing a basic amine linked to the heterocyclic scaffold through a linear alkyl chain of varying length also afforded good ChE inhibitors.
Among the tested compounds those bearing two basic side chains at 2- and 5-positions exhibited a strong dose-dependent antiproliferative activity.
Here, we confirmed the versatility of the diphenylamine skeleton by designing and synthesizing ER antagonist candidates bearing a basic alkylamino side chain on one of the two phenol groups of the diphenylamine agonist core structure.
Results of this docking study suggested that indoles bearing the basic tetrahydronaphthyridine group at position 4 can easily adopt the correct binding conformation and should be as potent as our current 5-substituted indole leads 3 and 4.
With the aim to explore the potentiality of new chemical scaffolds for the design of new antimalarials, a set of new indeno[2,1-c]quinolines bearing different basic heads has been synthesized and tested in vitro against chloroquine sensitive (CQ-S) and chloroquine resistant (CQ-R) strains of Plasmodium falciparum.
These intermediates are the first products to be formed in the result of an addition of the nucleophilic reactants, namely, 1-aryl-2-hydrazonoimidazolidines of the 1 6 type, bearing the basic nitrogen atom of the hydrazono moiety (N NH2), to the carbon carbon triple bond of the highly electrophilic alkyne, that is, DEAD.
The N-end rule predicts that proteins bearing charged basic (type 1, e.g. Arg or Lys) or large hydrophobic (type 2, e.g. Phe or Trp) N-termini are targeted more rapidly to the proteasomes.
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