Sentence examples for bear alterations from inspiring English sources

Moreover, nef genes are highly conserved in all primate lentiviruses (HIV-1, HIV-2, SIV) and data show that patients classified as long-term non-progressors bear alterations in the nef gene [ 8].

To date, ALK inhibitors show promise in the patient subset whose tumors bear ALK alterations, and substantial efforts are being made to target MYCN and its downstream targets.

Interestingly, it seems that even early mutants such as RutC-30 bear considerable alterations of their genome (Seidl et al. 2008).

DCs from patients with SLE could bear genetic alterations that made them prone to maturation under abnormal conditions, or they may be normal cells with an abnormal phenotype and behavior induced by the bizarre microenvironment from which they were obtained.

It is unclear whether this is due to the fact that NRAS signaling is incompletely extinguished by MEK inhibitors or if these tumors bear additional alterations that confer resistance.

As mentioned before, these models offer the advantage of evaluating the protective effects of VEGF on motor neurons that do not bear genetic alterations, which is the most common scenario in the actual human SALS disease.

The dystrophin defective mdx mouse, acknowledged model of Duchenne Muscular Dystrophy (DMD), bears outstanding alterations of the cortical architecture, that could be responsible for the cognitive impairment often accompanying this pathological condition.

Further laboratory work is needed to determine which sequence alterations bear functional consequences for the development of breast cancers.

To that end, I first repeated the search for significant targets detailed in the previous section comparing this time the expression of targets of the TF in samples bearing driver alterations of the partner and samples where neither the partner nor the TF bore driver alterations.

Among the most prevalent oral alterations in prematurely borne (i.e. a new borne of less than 37 weeks gestation) and low birth weight children (i.e. less than 2500 gram at birth) are hypoplasia and opacities in the dental enamel [ 13, 21- 23].

It is possible that MCF-7 cells and low-grade endometrial tumors bear additional genetic or epigenetic alterations that can antagonize the growth inhibitory and pro-death effects caused by prolonged and excessive EIG121 expression.