Treatment was classified into one of the following categories: active surveillance, radical prostatectomy, external beam radiotherapy, androgen deprivation therapy, low dose rate brachytherapy, high dose rate brachytherapy, or any combination of these.
Men were asked to identify primary treatment(s) received from a list (radical prostatectomy, external beam radiotherapy, androgen deprivation therapy (ADT), brachytherapy, chemotherapy, active surveillance/watchful waiting) with start and completion dates, and hospital(s) attended.
We also measured OPN pre- and posttreatment, following radical prostatectomy, external beam radiotherapy (EBRT), androgen deprivation (AD) or taxane-based chemotherapy.
Johnson et al. have studied the nPSA and tnPSA for 410 patients after definitive high dose (>75 Gy) external beam radiotherapy without androgen deprivation.
Cases who had external beam radiotherapy or androgen deprivation therapy, or the two combined, were older, had later stage disease, and had more comorbidity than those who received other treatments.
Recent trials have shown that the addition of external beam radiotherapy (EBRT) to androgen deprivation therapy (ADT) improves survival among men with locally advanced prostate cancer.
The main outcome measures were treatment with radical prostatectomy, any radiotherapy, external beam radiotherapy, brachytherapy or androgen deprivation therapy, and cancer staging.
Poor bowel function was a persistent problem for men who received external beam radiotherapy together with androgen deprivation therapy, and all men who underwent treatment for prostate cancer reported bowel bother.
Patients treated by either external beam radiotherapy with neo-adjuvant androgen deprivation (EBRT) or primary androgen deprivation therapy (PADT) only and with 5 year complete follow up data were identified from our hospital registry based at Addenbrookes Hospital, Cambridge.
Commonly, CRPC is treated with the continuation of androgen deprivation, chemotherapy, and external beam radiation therapy (EBRT).
Abbreviations: ADT, androgen deprivation therapy; EBRT, external beam radiotherapy; HDR, high dose rate; LDR, low dose rate; RP, radical prostatectomy; SD, standard deviation.
