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Another parameter evaluated was the degree of bead erosion.
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Irregular pores and cracks were observed on the beads, probably due to erosion of the polymer matrix.
The enteric polymer coat erodes in slightly alkaline media and the bead matrix undergoes swelling and erosion in SIF.
Minor beach erosion occurred.
Moderate beach erosion also occurred.
Elsewhere, minor beach erosion occurred.
Minimal beach erosion was reported.
Only minor beach erosion occurred.
The maximum erosion degree of the beads was 5% over 30 days of experiments.
The zero-order model did not fit the in vitro release data since the calcium-alginate/polymer mix beads were found to slowly and gradually undergo erosion during the in vitro release testing.
Calcium alginate beads swelled at pH 1.2 but underwent diffusion and erosion at pH 6.8.
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