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Portha and colleagues proposed that the link between the prenatal environment and adverse long-term effects could be written through epigenetic modifications of the conceptus.
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Potentially, epigenetic memory could be written only in the nucleation region, where mirror H3K36me3/H3K27me3 states do exist.
DNA methylation, the first identified epigenetic modification, is written by a family of DNA methyltransferases (DNMTs).
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