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Exact(6)

Bone remodeling requires that various stresses generated around the bone caused by the occlusal load applied to the implant be within an appropriate range.

The concentration of colonies and hyphae in lysis buffer should also be within an appropriate range (visible turbidity).

A CQA for the drug substance is a physical, chemical, biological, or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality.

Critical quality attributes (CQA) are physical, chemical, biological or microbiological properties or characteristics that must be within an appropriate limit, range or distribution to ensure the desired product quality, safety and efficacy.

The Annex to ICH Q8 defines CQAs as physical, chemical, biological or microbiological properties or characteristics that should be within an appropriate limit, range or distribution to ensure the desired product quality, safety/immunogenicity, efficacy and pharmacodynamics/pharmacokinetics (Table  II).

A critical quality attribute (CQA) is defined as a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range or distribution to ensure the desired product quality, safety and efficacy (Shinkawa et al. 2003).

Similar(53)

I.S.S. did so because it felt Clearwire's options were limited and the price was within an appropriate range, but Glass Lewis disagreed.

Besides, when the fitted initial porosity is within an appropriate range, the fitted initial porosity ought to be used.

Thus, the availability of choices could help to moderate intake if the portions offered are within an appropriate range for energy needs.

As the CCR model does not incorporate prior knowledge of the relative importance of inputs and outputs in estimating weights [ 25], we used the DEA model with an assurance region (AR), setting weight boundaries for outputs so that the relative importance of each of the services contributing to the efficiency is within an appropriate range; these are described in Additional file 1.

Of note, neither of the patients with meningococcal sepsis had received vaccination against the specific strain of their infection, at the time of the infections serum bactericidal antibody values were within an appropriate range and both infections resolved with treatment and without sequelae.

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