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QFA screen data presented in this paper along with data from (Andrew et al. 2013) can be visualized here: http://bsu-srv.ncl.ac.uk/dixy-pol/viz/.

QFA screen data presented in this paper, along with data from Andrew et al. (2013), can be visualized here: http://research.ncl.ac.uk/qfa/Dubarry2015/.ac.uk/qfa/Dubarry2015/

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The subspecific origin, haplotype diversity and identity-by-descent map of laboratory strains can be visualized at http://msub.csbio.unc.edu/PhylogenyTool.html.html

The resulting eight YUC4 promoter sequences were aligned by mVISTA (http://genome.lbl.gov/vista/mvista/submit.shtml), and the promoter sequences were aligned using CLUSTALW (http://www.genome.jp/tools/clustalw/). Conserved cis-elements were visualized by WebLogo (http://weblogo.berkeley.edu).edu

Phylogenetic trees were visualized with iTOL (http://itol.embl.de 49.de 49

The phylogenetic tree was visualized by FigTree (http://tree.bio.ed.ac.uk/software/figtree/).ac.uk/software/figtree/

Lollipop plots of B2M mutations found in TCGA data sets were visualized using cbioportal (http://www.cbioportal.org/), using the web query interface39, 40.

The structural interactions were visualized using PyMOL (http://www.pymol.org).org

The CYP3A45 model was visualized using Pymol (http://www.pymol.org).org

Phylogenies were visualized using Figtree (http://tree.bio.ed.ac.uk/software/figtree/).ac.uk/software/figtree/

Resulting brain overlap images were visualized using MRIcro (http://cnl.web.arizona.edu/mricro.htm).edu/mricro.htm

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