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It is possible that beneficial effects of vitamin D may be via modulation of innate immunity, rather than cell-mediated immunity.
The mechanism by which probiotics reduce diarrhoea may be via modulation of the host immune system or on the composition of the GI microbiota and their by-products.
Hence, this is more plausible that mechanism of neuroprotective action of anthocyanin may be via modulation of signal transduction processes and/or gene expression in the brain tissue [ 151].
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An attractive hypothesis for the potential chemopreventive actions of isoflavones is via modulation of endocrine function.
The major mechanism of regulation of cell cycle for identified genes (CCNG1, CDKN1A, FGF2, GADD45A and SHC1) is via modulation of protein kinase activity driving the cell cycle machinery.
In each case, reduced disease severity is via modulation of the pro- and anti-inflammatory cytokine balance, resulting in reduced TNF-α and IL-17 and up-regulated IL-4 and IL-10 production.
In conclusion, our study indicates that the antiproliferative and apoptotic effects of these three xanthones on human melanoma SK-MEL-28 cell line are via modulation of the genes involved in the cell cycle and apoptosis pathway, together with downregulation of the mRNA expression of Akt1, NF κB, and BRAF V600E.
That aside, is the prediction that if you were to KO KAP1 and see the effect observed in Figure 1D then the addition of chloroquinone (thought to be active via modulation of KAP1) to KAP1 KO cells should have no incremental impact on HCMV reactivation if the authors predictions are true i.e. if KAP1 mediated repression is deleted by siRNA then any effects of chloroquinone should be abrogated.
Thus, NPFF induced satiety may be mediated via modulation of the chick's innate opioid-associated orexigenic system.
Taken together, these data suggest that protective effects of quercetin against oxidative injuries of H9c2 cardiomyoblasts may be achieved via modulation of mitochondrial dysfunction and inhibition of caspase activity.
Our study demonstrates protective effect of dietary nitrate in renal IR injury that may be mediated via modulation of oxidative stress and inflammatory responses.
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