Sentence examples for be via blockade of from inspiring English sources

In this context, our observation that 5-HT6R administrationincreaseson increases PVH neuronal activation may be via blockade of 5-HT action on inhibitory ARC AgRP/GABA neurons, promoting the disinhibition of downstream anorectic PVH neurons.

Without such controls, at the completion of this replicate, a conclusion that the mechanism is via blockade of the interaction of CD47 with SIRPa, (as in title) is not possible.

In this study, we demonstrate a critical prosurvival role for the IGF-1/MEK1signaling axis in breast cancer cells undergoing antiestrogen and antiprogestin treatment and uniquely demonstrate that the underlying mechanism of MEK1-mediated survival is via blockade of the proapoptotic action of the BH3-only protein BimEL.

An alternative route of PGE2 inhibition is via the blockade of PGE synthase (PGES), a major route of conversion of prostaglandin H2 to PGE2.

The group's finding that RTA could be post-transcriptionally down-regulated via blockade of Mnk activity is of particular importance, however, as it suggests an additional path with which to block lytic KSHV, particularly in patient tumors that are resistant to rapamycin inhibition.

This study shows that atropine and other muscarinic antagonists are likely to exert their beneficial effects via blockade of the M2 muscarinic receptor subtype.

Because they relax smooth muscle and reduce gastrointestinal secretions via blockade of muscarinic receptors, they are also useful in the medical management of terminal bowel obstruction.

Loss of thrombomodulin was shown to be via Sec61 translocation blockade, and because this is a constitutively expressed protein, it was lost steadily from the cells at the known turnover rate.

This hypothesis is consistent with reports that sanshool activates mechanosensitive neurons via blockade of potassium leak channels [11].

Recently, it was demonstrated in mice that selective depletion of alloantigen T effector cells via blockade of co-stimulatory molecules plus administration of rapamycin permitted acceptance of the allograft [ 31, 32].

Inhibition of VEGFR-2 kinase has been highlighted as one of the well-defined strategies to suppress tumor growth via blockade of angiogenesis.