Sentence examples for be via activation of from inspiring English sources

The beneficial activity of prostacyclin (analogues) in PH is presumed to be via activation of the Gs-coupled IP receptor, despite the fact that these compounds can activate other prostanoid receptors (Narumiya et al., 1999); however, recent evidence also supports a role for peroxisome proliferator activated receptors (PPARs; see below) in the underlying mechanism.

The mechanism of induction of E-selectin expression is likely to be via activation of NF κB by reactive oxygen intermediates generated by irradiation [ 10].

Acquired resistance to VEGF blockade in various mouse models appears to be via activation of VEGF-independent pathways with secondary activation of proangiogenic ligands from the FGF family [ 5, 6].

One of the mechanisms by which depression may contribute to disruptions in glucose metabolism, central adiposity, and ultimately type 2 diabetes is thought to be via activation of the HPA axis.

Indeed, the increase in proliferation rate observed in prostate cancer cell line models in response to IL-6 has been demonstrate to be via activation of STAT3 (Dhir et al, 2002; Godoy-Tundidor et al, 2005; Sanford and Dewille, 2005).

Therefore, the present observations showed that PEMF and/or osteo-induction medium-induced the osteogenic differentiation of AECs may be via activation of both BMP-2 and Wnt/β-catenin signaling.

Another mechanism by which ICs may lead to tissue damage is via activation of activating FcγRs, upon binding of immunoglobulin Fc regions by FcγR-expressing cells [ 29].

Metformin has several potential mechanisms of action [ 265, 266] but one of the most well characterised is via activation of AMP-activated protein kinase (AMPK) an intracellular signalling enzyme that is normally activated when the ratio of AMP to ATP in the cell rises.

One of the mechanisms by which ionising radiation has been shown to induce apoptosis is via activation of the stress-activated protein kinase pathway, also known as the c-Jun N-terminal kinase (SAPK/JNK) pathway (Verheij et al, 1996).

We hypothesized that melanogenesis was via activation of PPAR γ, which elevated the tyrosinase activity.

Another way that apoptosis can be induced is following ligation of members of the tumor necrosis factor receptor (TNFR) superfamily known as 'death receptors' such as TNFR1, CD95, and TRAIL receptors that can signal FADD to activate caspase 8. Yet another mechanism for cell death is via activation of caspase 1 by one of several kinds of inflammasomes, a process termed 'pyroptosis'pyroptosis