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Since uncontrolled proteolysis can be very deleterious for tissues, proteases (other than those found in the digestive track) are stored as inactive pro-enzymes that are activated only for specific and localized tasks limited in time.
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Bosworth tells me "I think the alternatives for adblockers would be very deleterious to the user experience".
In the absence of a device for bedside testing, this time delay can be very deleterious in cases of life-threatening haemorrhage.
"You change the board and upset the management and it could be very deleterious to the business".
There needs to be recognition of the consequences of not doing so, which are very deleterious not just for individual countries but potentially for others around the world.
The persistence model predicts clustering of genes whose deletion is very deleterious as is the case for essential genes (Fang et al. 2008).
High IL-12 expression is very deleterious during pregnancy[45].
Theoretically, even a minimal amount of sex may be very crucial for unisexuals to bypass a fatal accumulation of deleterious mutations [ 39] and it could be particularly significant for lineages to maintain long-term survival [ 17].
This would indicate that negative selection would be very effective in eliminating even mild deleterious variants.
Altogether, these analyses showed that 517373%) of the new missense variations were very probably deleterious, whereas 13 (19%) were very probably benign.
One objection to this hypothesis is that it would be very hard to fix a mutation as deleterious as bem1∆.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com