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However, auditing can be very challenging when the parties do not blindly trust each other, which is expected to be the common case for large grid deployments.
Intraoperative detection of F-FDG-avid tissue sites during F-FDG-directed surgery can be very challenging when utilizing gamma detection probes that rely on a fixed target-to-background (T/B) ratio (ratiometric threshold) for determination of probe positivity.
Therefore, the in situ intraoperative detection and localization of F-FDG-avid tissue sites during F-FDG-directed surgery can be very challenging when utilizing standard gamma detection probes and PET probes that rely solely on a fixed T/B ratio (i.e., ratiometric threshold) as the threshold for probe positivity for the identification of F-FDG-avid tissue sites.
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"But it's very challenging when something goes wrong and they have to intervene to get trains moving".
Moreover, the computation is very challenging when the accurate cutter motion of practical machining is applied to calculate the envelope surface.
Detection of cut vertices is trivial if the global knowledge of the whole system is known but it is very challenging when the global knowledge is not available.
The simple act of thinking is very challenging when the background noise is so invasive and the pace is preset at whirlwind speed.
"It's very challenging when a child goes through that awkward adolescent period, all that pain, all that awkwardness gets amplified if you're also known and living some kind of a celebrity life".
Rapid and effective detection and identification of emerging microbiological threats and potential biowarfare agents is very challenging when using traditional culture-based methods.
The differential diagnosis between septic and aseptic loosening can be very challenging, especially when no previous radiographs are available.
Being a parent can be very challenging, especially when it comes to raising a child accompanied by the excessive demands of work.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com