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However, the practical impact of this treatment needs to be verified further in future clinical trials, given the genetic and functional heterogeneity of CSCs (Kreso and Dick, 2014) and the complexity of the tumor microenvironment (Plaks et al., 2015).
However, this notion needs to be verified further.
However this observation needs to be verified further using broader taxon sampling.
Another, possible way through which the authenticity of the manually curated data could be verified further is by the aggregators and/or various hybrid databases.
Therefore, our hypothesis concerning the selected molecules should be verified further for in vitro and in vivo inhibitory activities for consideration as an effective drug (Table 4).
Based on our data, we propose a hypothesis that early treatment which can activate the process of anti-apoptosis within 12 h is essential for decreasing cell death; and this hypothesis should be verified further.
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Differential regulation of histone H2B and NIF-1 were verified further by ELISA (urine, n?=?166) and immunohistochemistry (tissue samples, n?=?32) [179].
The significance of the positive regulation was verified further by the fact that the Per2::luc reporter gene that could not be transactivated by PER1/2 (delta-Per2::luc) lost the phase delay observed in wild-type Per2::luc.
The closer relationship between NGMGCTs and ESCs was verified further by hierarchical clustering.
Thereafter, this was verified further in hepG2, HSG, and SHG44 cells, as shown in Figure S2.
These results were verified further in both cell lines using siRNA to specifically target IGF-IR (Additional file 2, Figure S1).
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