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The Ala82Phe and Ala82Trp mutants are also very much more effective catalysts of indole hydroxylation than the wild-type enzyme, suggesting that they will be valuable starting points for the design of mutants to catalyse synthetically useful hydroxylation reactions.
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Subsets of genes expressed in mammalian stem cells that cause phenotypes in Drosophila Nbs may represent valuable starting points for functional analyses and are provided in Table S2.
Nonetheless, the interactome studies have proven to be very valuable starting points for predicting functions of unknown proteins when found to interact with known partners.
In search of bioactive compounds, many exogenous natural products were demonstrated to have valuable starting points for medicinal chemistry.
All compounds passing these filters were regarded as, in general, valuable starting points for medicinal chemistry programmes and are used for virtual screening campaigns (VS set).
Three different libraries were assembled: a virtual screening set representing valuable starting points for lead optimisation programmes, a HTS library intended to be a diverse subset of these compounds, and a kinase library containing compounds that are likely to inhibit kinases.
Fragment-based design might deliver valuable starting points for the discovery of novel MBL inhibitors.
If EB are indeed confirmed to be influential in the solution of medical problems, this approach could prove to be a very valuable starting point for improving clinical reasoning.
These compounds represent novel valuable starting point in the development of novel antibacterial agents.
Such "privileged scaffolds" are valuable as starting points for the engineering of new bioactive molecules.
This book is a valuable starting point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com