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There are hundreds of identified candidate biomarkers, but these must be validated to prove their specificity and clinical relevance.
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Although the technology used has been shown to be ready for clinical practice [ 16], and can be used as one parameter in combination with current clinical parameters, these signatures need to be prospectively validated to prove their superiority and benefit above and beyond the use of standard clinico-pathological prognosis variables to guide the choice of adjuvant therapy.
This technique allows the description of potential targets, which must be biologically validated, to prove they carry essential functions.
The models developed were validated and proved to be valid when considering different data sets.
As the location space continues to be validated, each company is out to prove that it's the one that will be the next big thing — the one people will remember.
But even if a signature is validated, proven to be accurate, and generalizable, there is still a long way to go before it is part of medical decision making.
The BMQ-D has been validated and proved to be suitable to measure patients' beliefs in medicine in German primary care settings [ 26].
Each assay has previously been validated and proven to be sensitive (to a level of 1 10 DNA copies/reaction) and specific (does not detect other bacteria at a concentration of 10copies/rxn).
DTVP has been validated and proved to be internally consistent when compared to other established tools assessing visual perception, such as Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) and Test of Visual Perceptual Skills (TVPS-3) [ 24].
It was validated and proved to be linear in the 40 400 ng/ml range.
The mathematical model developed was validated and proven to be statistically adequate and accurate in predicting the response.
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CEO of Professional Science Editing for Scientists @ prosciediting.com