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Ideally, where surrogate outcomes are substituted for clinical endpoints in order to predict clinical benefit, these should be validated to demonstrate the relationship between surrogate and patient-related outcome.
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In particular, the power-switching scheme is validated to demonstrate that the scheme proposed in this paper can solve these key problems for international applications.
Primer sets were validated to demonstrate that efficiencies of target and reference were approximately equal.
A physical based model is developed and validated to demonstrate that uniform cathode ageing does not to affect the evolution of impedance spectra.
One type of study, guideline studies, uses prescribed methods that have been agreed upon by committees and validated to demonstrate their reproducibility [ 35].
The proposed approach is applied to a prototype case study designed from scratch, in order to be validated and to demonstrate its potentiality.
Although software agreement does not necessarily correspond with the validity of the calls, the program-specific calls tended not to be validated, as demonstrated below.
The method was validated, demonstrating to be accurate and precise (repeatability and intermediate precision levels) within the corresponding linear ranges of PRI (0.1 1.5 mg ml−1; r = 0.9983, n = 18) and both impurities (0.1 1.3% relative to PRI, r = 0.9996 and 0.9995 for ELI and NOX, respectively, n = 18).
The C-BDI-II has been validated and demonstrated to have satisfactory validity and reliability [ 25].
An improved proposed protocol that consisted of subjecting seeds to soaking, the application of GA3 and KNO3, cold stratification, heat shock, and light irradiation was validated and demonstrated to be highly effective, with seed germination success greater than 60% being observed at 3 days and final germination reaching a plateau at 6 days.
These unvalidated tools performed well in a single cohort of patients, but results need to be validated in patients from another centre to demonstrate the usefulness of the scoring tool [ 11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com