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Last, these data must be validated on an independent dataset for more reliability.
In that regard, the QSERR models that are derived must be validated on an external test set, separate from the training set of compounds used to derive those models.
As well, the current model can be validated on an ongoing basis, before and concurrent with adding requisite complexities.
Our gene signature is yet to be validated on an external population.
Additionally, these instruments should be validated on an Italian sample and translated into Italian, otherwise they could cause biases.
A Spanish version of this test will be validated on an independent sample to be used in the study.
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However, it should be noted the use of HYPR should be validated on a study or tracer basis.
Finally, the model will be validated on a surface which has a statistical roughness resulting from various grinding processes.
Optimally, cut-off points should be validated on a larger patient cohort.
These need to be validated on a larger scale.
This second group of markers need to be validated on a larger cohort.
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