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However, potential benefit needs to be validated in randomized, controlled trials.
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We should emphasize that selection criteria for early versus late tracheostomy have not been validated in randomized controlled trials, although there are certain variables that can help the intensivist in predicting who is likely to need prolonged mechanical ventilation and possibly tracheostomy.
However, the present findings may need to be validated in larger randomized prospective trials.
New molecular CRC detection methods are currently being evaluated, but most of these still have to be validated in large, randomized trials prior to implementation in the clinic.
Future adaptations could also power interactive clinical decision aids for planning the management of individual patients, an approach that itself could be validated in a randomized trial.
These findings and their significance need to be validated in a prospective randomized controlled study.
These findings need to be validated in a prospective, randomized clinical trial.
Further well-designed clinical trials will be required to investigate this possibility and any routine application of less intensive therapy in responsive patients must first be validated in well-designed randomized trials.
Such new findings represent a lower level of evidence and should be validated in a second randomized PoC study designed with the new clinical benefit ID hypothesis as primary.
The results of this study should be validated in a double-blinded randomized control trial.
To overcome this problem one might argue that the arterial puncture training simulator must consist of a more arterial tissue-like texture and be validated in a proficiency-guided randomized transfer environment.
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