Exact(2)
Our hypotheses need to be validated in randomised studies exploring the optimal duration of exemestane administration.
Nevertheless, they need to be validated in randomised controlled clinical trials.
Similar(57)
This hypothesis needs to be validated in a randomised clinical trial format.
The findings of this study need to be validated in a randomised control trial: this is now taking place and recruitment to the 12-month follow-up clinical trial is now complete.
Ideally, the overall survival benefit conferred by neoadjuvant treatment needs to be validated in a prospective randomised trial in the palliative setting.
However, the preliminary and hypothesis-generating results of this pilot study must be validated in larger, prospective, multicentre, high quality randomised clinical trials not only evaluating clinical benefits but also paralleled by evaluation of cost-effectiveness applying a micro-costing approach.
However, this project was not a randomised intervention; therefore, the results are subject to bias and the findings need to be validated in a more formal research setting.
It should be acknowledged that these patients did not participate in a prospective randomised trial, and the predictive value of survivin CNR in tamoxifen-treated patients should be validated in such a setting.
The efficacy of these agents has been validated in several randomised controlled trials and meta-analyses [ 10– 10].
Smyth and Openshaw[ 10] in a Lancet review article conclude "Neither oxygen therapy, nor fluid replacement strategies have been validated in large randomised controlled trials, although the dangers of hyponatraemic fluid overload are recognised.
The role of pulmonary metastectomy has not been validated in a prospective randomised trial to date however based on published data, has been standard practice for selected patients at our intuitions for more than a decade.
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