These results should be validated in larger studies.
All of the biomarkers identified so far must be validated in larger independent clinical cohorts.
New sequential procedures with less stressful circulatory effects based on theoretical consideration of lithium pharmacokinetics are proposed, but need to be validated in larger studies.
If these positive findings can be validated in larger studies, USE could lower the number of hemi-thyroidectomies performed in this subgroup.
In this line, although these encouraging results have been obtained from two independent cohorts of patients from two different and geographically remote hospital centers, they should be validated in larger cohort studies performed by other groups.
Our data need to be validated in larger studies as this is important information for the clinician in order to make better informed decisions regarding mode of transportation for these critically ill individuals.
These observations remain to be validated in larger clinical trials eventually designed also to address the efficacy of therapeutic mAb to immune check-point(s) within multimodality therapies for brain metastases.
Therefore, the findings should be validated in larger, prospective studies.
Importantly, from a biomarker development perspective, these findings will need to be validated in larger cohort of independent clinical specimens.
In any case, the discrepancies between both studies suggest that these results need to be validated in larger and more diverse populations.
Large-scale production of this protein is certainly an attractive approach to facilitate the speed at which therapeutic efficacy can be validated in larger animal models of tumor growth, angiogenesis, and neurodegenerations without the drawbacks of viral mediated transfer of the gene.
