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Although the hpVIR test is favoured by its ability to be type specific, the self-sampling device Qvintip has been validated in combination with the FDA-approved HC2 method (Stenvall et al, 2007; Sanner et al, 2009).

22 The VEINES questionnaire would be a candidate, but such a combination must be validated in appropriately designed studies and take into account the apparent overlap between the Villalta score and the VEINES-scores; all items in the Sym score are covered in the QOL score, 2/3 of Sym items are covered in Villalta and 1/4 of the QOL items are covered in Villalta.

Predicted drug combinations should be validated in cancer cell lines and in relevant in vivo human disease models such as patient-derived tumor xenografts [81].

Prostate MRI biomarker combinations need to be validated in the context of well-designed, clinically relevant trials, particularly those that are associated with tissue sampling and in studies that incorporate accepted clinical efficacy end points (for clinical validation), where there is minimization of patient selection bias.

However, this combination still needs to be validated in animal model and clinical trials.

The presence of heterotic phenotypes in these NILs was validated in different genetic combinations and growing conditions [ 25, 26].

The efficacy and the toxicity of AZD1152 alone and in combination with gemcitabine were validated in pancreatic tumour xenograft model.

Thus, in comparison with a reference concrete containing no MK and for an identical granular skeleton, the combination clinker/MK was validated in the precast factory in full-scale trials for slip-forming (25% replacement) and self-compacting (17.5% replacement) concrete applications: compressive strength and porosity were not affected.

Although the ABRS and DPTRS combination has not been validated in a different population, the areas under the ROC curve were very high in the internal validation.

All models were validated in Sample Set A, resulting in three combinations, REG1B + CA19.9, SYCN + REG1B + CA19.9, and AGR2 + REG1B + CA19.9, which were found to significantly improve the AUC of CA19.9 alone (p = 0.001, p = 0.030, p = 0.004, respectively) (Table  4).

The method is validated in Section 'Results and discussion' and the best combination of attributes is identified.

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