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In contrast, patients with logistic EuroScore >40% do poorly and survive on average little more than 1 year, suggesting that indication for TAVI and risk-to-benefit ratio should be validated carefully in each single case.
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To make the best use of our current therapeutic tools, new predictive biomarkers must be validated in RCC in carefully designed trials able to discriminate between prognostic and predictive markers.
Questionnaires will need to be validated with carefully designed studies that involve personal sampling or biologic monitoring.
Entries in repertory rubrics can be validated, but must still be handled carefully.
GIS-based exposure models, now common in environmental epidemiology, should be validated to the spatial extent of the cohort examined, and spatial patterns in stressors and pollution, at multiple levels, should be carefully considered to avoid spatial misclassification and confounding.
Anything can be validated.
All cases of alternative MDS processing in Oxytricha have been validated by carefully examining the precise order of DNA segments in the micronuclear genome and mapping micronuclear genomic sequencing reads to assess the copy number of shared MDSs.
The process and resulting system model are validated by carefully selected subject matter experts during training sessions in high-fidelity flight simulators.
These criteria were updated in 2009 to expand their use to patients with underlying conduction abnormalities, but these versions have thus far only been validated in small and carefully selected populations.
Both models have been validated in a survey which confirmed that both models carefully predicted the magnetic field distribution detected through on-site measurements around a high voltage (132 kilovolts) power line in the bordering Bologna province [ 10].
It has not yet been validated in Kenya, but as for the previous 2004 survey, it was carefully scrutinised by local clinicians for content validity within the local cultural context.
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