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We noted in the discussion the possibility that hit calls that failed to be validated as leads for differentiation or proliferation assays may have direct effects on the insulin promoter.
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Among 20 Hit I compounds tested, 11 were validated as Lead I drugs that promoted endocrine differentiation (Table 1).
To clarify that stimulation of progenitor cell proliferation was a possibility among Lead I compounds we have edited the text to read as follows: "Among 20 Hit I compounds tested, eleven were validated as Lead I drugs that promoted endocrine differentiation (Table 1).
As half of the patients were on anticoagulant therapy, many of the candidate markers of coagulation or some of the protease inhibitors known to be involved in the coagulation cascade, could not be validated as this could have led to erroneous estimation of their circulating levels under the disease condition.
I don't need to be validated as "lovable" by being given an appropriately "romantic" love trophy.
But in the 50s any of these could be validated as real threats by rolling out a map of China.
The collective also teaches that the voices should be validated as a means to seeking meaning, even if only metaphorical.
All primers were validated as described [55].
Assays were validated as previously described [16], [17].
Such indicators need to be validated and operationalized as part of quality improvement efforts, to detect where missed opportunities and/or substandard care can lead to disaster.
Results that could not be validated by SNT were classified as non-interpretable, which may have lead to an underestimation of the final seroprevalence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com