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New molecular techniques, especially PCR assays, still need to be validated and further developed in different settings.
Of course, the results of our study should be validated and further refined in other large, independent and well-characterised cohorts.
These miRNAs and their target genes, reported in advanced stage RB, needs to be validated and, further, to be used either as biomarkers and/or for targeted therapy.
These results have to be validated and further explored, but if there are such fundamental differences between tumors predominantly with angiogenesis versus co-optioned blood supply this may have major impact on targeted therapy strategies.
Complementary to any other disease gene and SNP association study, this approach can help to prioritize the genes that need to be validated and further help to elucidate the genetic contribution to the development of cancer.
The limitations of the current lipid force fields regarding the lipid head group order parameters are discussed in detail in the paper of Botan et al. [31] Nevertheless, the effects of PE head group and the vinyl ether bond on the head group orientation presented in this study can be validated and further scrutinized by NMR measurements in the future.
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Gene ontology analysis using DAVID bioinformatics resources tools [19], [57] of the 49 identified hits, including the 16 that were validated and further characterised, has provided some links between the MG phenotype and certain molecular functions (Figure 8C).
APACHE III was developed in 1991 [ 5] and was validated and further updated in 1998 [ 6].
The models were validated and further used for docking analysis with sulphate inhibitor.
Results were validated and further compared with expression-based prognostic profiles using The Netherlands Cancer Institute microarray data set reported by Fan and colleagues.
These modeling predictions were validated and further refined by ex vivo fluence rate and thermographic measurements, as well as in vivo plasmonic photothermal heating of PEG-NR-containing ovarian tumors and nontumor tissues.
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be investigated and further
be extended and further
be applied and further
be modeled and further
be supported and further
be lost and further
be requested and further
be retained and further
be normalized and further
be obtained and further
be shared and further
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