Results: After ensuring that the production of a new radiopharmaceutical is robust and repeatable and all analytical methods including sterility and endotoxin tests are validated, the process can be validated according to a written validation plan.
To come to more standardized procedures for method evaluation, the European Commission has issued a decision on method validation, 2002/657/EC [ 54], which describes how analytical methods should be validated according to common procedures and performance criteria.
The knowledge is usually derived from expertise in specific areas and has to be validated according to a different methodology than is used in conventional systems because the knowledge is symbolic.
Therefore, the RT-PCR methods that are used in pathogen-diagnosis laboratories must be validated according to the specificity of the primer set and the one-step or two-step RT-PCR method employed, using either the target primer set or oligo dT + random hexamer.
For OBJ and OFF files (formats without semantics and used mostly for visualisation), each primitive will be validated according to the ISO19107 rules, therefore one must specify how the primitive(s) should be validated (as MultiSurface, CompositeSurface, or Solid).
The results of the sheet forming analysis can be validated according to the graphs of the external work and internal energy because based on the ABAQUS given mass criteria (mass scale), the internal energy must be about five times than the kinetic energy, which it can be observed in Fig. 7.
