We suggest that replication of survival data, such as ours and those of the GH dwarfs [17], [18], [19], [20], [21], [22], will significantly help increase confidence in exactly what genetically modified mice are valid models of retarded aging [13], [14].
Citation bias has also been used to claim that animal and cell culture experiments are valid models of inclusion body myositis, in 17 papers.
In summary, the in vitro phosphorylation and the phosphatase experiments strongly support that UNG2 phosphomimicking mutants are valid models for studying the functional consequences of in vivo UNG phosphorylation.
Together the behavioral results reviewed above demonstrating spatiotemporal and motor phenotypes in CGG KI and Fmr1 KO mice results suggest that the CGG KI and Fmr1 KO mouse models are valid models for evaluating any behavioral effects of the Fragile X Premutation and Full Mutation.
Both are valid models; each theory of change achieves some of management's goals, either explicitly or implicitly.
A system that is incomplete in the latter sense can nevertheless be complete in the sense that all the relevant logical truths are valid model-theoretical consequences of the system.
Although there are many valid models of screening, evaluation and care, the need for a simple, rapid screening scale administered by non-specialists would fill one of the many gaps in responding to the mental health needs of young children in humanitarian contexts.
As partial behavioral changes based on the stage effects of the Transtheoretical model can be incorporated in economic evaluations, this may also be valid for other models of behavioral change [ 4], such as the Ajzen's Theory of Planned Behavior [ 35, 36] for which ample empirical support is available.
In summary, the gerbil elevated plus-maze appears to be a valid model of anxiety and neophobia for detecting anxiolytic and anxiogenic drugs, similar to other anxiety models in gerbils (Ballard et al. 2001; File et al. 2001).
