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Collectively, our data suggest that the "intrinsic" PC1 signature, underpinned by robust EMT biology, is highly prognostic for colon cancer recurrence, may be useful to subclassify more than one type of cancer, and may provide a means of identifying sensitive subpopulations for the next generation of novel therapeutics.
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Since the significance of basal cytokeratin or EGFR overexpression is not known and we lack validated assays, these features should not be used to subclassify TN tumours.
Therefore, new factors, which can be used to subclassify grade 2 tumours, are needed for determining treatment strategy in this category.
Only tumour size and radiation treatment were independent predictors of survival in this population and may be used to subclassify these patients.
Clinically, smoking history can be used to subclassify histologically similar tumors based on smoking status-associated molecular and clinical features, and can inform therapeutic decisions [ 3– 7].
In accordance with other international series, it was agreed that the Paris classification and the term 'laterally spreading type polyp' (LST) may be used to subclassify lesions further.
However, other approaches have been used to subclassify cases in psychiatry in relatively small samples.
The immunostaining results for CD10, BCL6 and MUM1 were used to subclassify the cases into GCB and non-GCB subtypes according to Hans' algorithms (Fig. 1).
They could even be useful to medicine.
How might they be useful to you?
This will be useful to escape.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com