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Although GWAS studies are important for discovery of regions of the genome important in disease, they have not always proven to be useful in validation of functional markers due to the all-inclusive approach applied for cases and controls.
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The main requirement for a measure of discrimination to be useful in external validation is that it be evaluable in the validation dataset.
Indeed, the whole-proteome SIL standard is unlikely to be useful in the validation phase of biomarker discovery.
This method has been shown to be useful in preparing validation artifacts for fluorescence[ 7] and absorbance[ 5] microscopy of biological samples.
Several authors have expressed the need to use the BDI-II to test the models in student populations across cultures because of their homogeneity and comparability [ 14, 16- 18, 26, 27, 29]; and the sample of college students was found to be useful in the original validation studies of the BDI-II because it is a close approximation to the general population [ 12].
Each condition has a number of CSF proteins that can be useful in providing candidates for future validation studies and insights on the respective mechanisms of pathogenesis.
Other measuring systems require further development and validation to be useful in the ICU.
The findings in our work would be useful in selecting candidate genes for functional validation studies of PTR members in rice.
These results suggest that the levels of PY-Shc and p66 Shc proteins in primary tumors identify patients at high risk for relapsing despite treatment with tamoxifen and therefore with further validation may be useful in guiding clinicians to select alternative adjuvant treatment strategies.
Model error correlation with the incident offshore wave energy, and between neighboring validation sites, may be useful in identifying sources of regional modeling errors.
Because of the low power of these studies, future investigations regarding the validation therapy may be useful in determining whether these positive results may be expanded upon.
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