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This suggests that mechanical stimuli may be useful in modulating chondrocyte metabolism in tissue engineering systems using fibrillar protein scaffolds.
Antagonizing Ets-1 might be of benefit in attenuating CCN2 expression in fibrosis, arthritis and cancer, and may be useful in modulating the outcome of these disorders.
Specifically, inhibiting ceramide synthase 2 may be useful in modulating ceramide synthesis and signaling [ 34] in CAD patients who show aberrant ceramide metabolism and verbal memory decline.
Our studies indicate that clinically achievable concentrations of sulphasalazine may be useful in modulating cisplatin resistance in malignancies with increased GST-pi content.
27 Clinical experience suggests that selective serotonin reuptake inhibitors may be useful in modulating intrusive or compulsive behaviours in some patients.
A number of studies have now shown that PPIs can be useful in modulating tumor acidification and restoring chemotherapeutic sensitivity in drug-resistant cancer cells both in vitro and in vivo [ 58, 103– 106].
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Several groups have also shown that peptides mimicking specific sequences conjugated to palmitic acid are useful in modulating specific pathways (Cisowski et al, 2011; Valente et al, 2011).
This routing of signals could be useful in designing computing circuits modulated by chemicals and other external stimuli.
Finally, the polymersomes with a tailored permeability will be useful in future studies to modulate the release rate of various therapeutic molecules and ultimately improve the quality of diagnosis and treatment of diverse diseases.
This data has provided new insights into the binding and cleavage of C4 by MASP-2, which may be useful in the design of molecules that modulate this important interaction required to activate the lectin pathway of complement.
This altered pharmacokinetics of liposome-encapsulated doxorubicin, providing enhanced therapeutic advantage and the ability to modulate multidrug resistance, could be useful in a clinical setting.
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