Physiologically based PK (PBPK) models and simulations are very useful mechanistic tools to achieve these goals because they can be used to simultaneously evaluate multiple intrinsic and extrinsic factors that influence PK through a single, unifying model structure.
The experiments show that the new all-optical method can indeed be used to simultaneously record and interfere with the activity of neuronal populations.
Different approaches may be used to simultaneously identify multiple CTC-specific markers for biological characterization; yet awareness of associated pitfalls is also important.
The developed methodology is widely applicable and can be used to simultaneously obtain reliable, cost-effective and continuous estimates of SSC, POC and PN with a single sensor.
These initial in vitro results validate the proposed multiple contrast agent relaxation model and demonstrate a new quantitative imaging methodology that can be used to simultaneously generate concentration maps for two different MRI contrast agents.
For example, two targeted MRI contrast agents could be used to simultaneously track drug delivery and therapeutic impact in cancer treatment (e.g., a therapeutic agent46 labeled with gadolinium, and a second agent targeted to apoptosis47 labeled with dysprosium).
Laser patterning is a simple and flexible microfabrication technology that can be used to simultaneously reduce a graphene oxide (GO) film and scribe a reduced-graphene-oxide (rGO) pattern in designed geometries with micrometer resolution12,13,29.
When assembled into an array, MPFDs can be used to simultaneously monitor the neutron flux at multiple locations within the reactor.
Due to its generally higher speed, sensitivity, reproducibility and specificity with respect to HPLC, it can be used to simultaneously separate and determinate multi component steroid mixtures.
Here, we present evidence that imaging spectroscopy data can be used to simultaneously predict Vcmax and its sensitivity to temperature (EV) at the canopy scale.
This paper demonstrates how transformers which have historically been used for impedance matching and/or voltage and current scaling purposes can be used to simultaneously filter signals.
