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Importantly, traditional Chinese medicine can be used systemically to accelerate bone formation or diminish bone resorption in order to treat bone diseases.
Instead, based on published work, agonists and antagonists of specific signaling pathways (some already developed and some FDA approved or in clinical trials), could be used systemically to quickly reset tissue stem cells residing in old organs to their "young" robust regenerative capacity, e.g. overriding the aged niche and its altered molecular cues.
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Clonidine and other α-2 agonists such as dexmedetomidine have also been used systemically to inhibit sensory transmission in the spinal cord by block of pre- and postsynaptic membrane excitability and intra-articularly following joint replacement.
We therefore aimed to identify an alternative stimulus to UVB as a TRAIL sensitizer that would engage a similar biochemical mechanism to be used systemically.
GTP implants have the potential to be used systemically and locally at the tumor site as an alternative strategy.
CD95L can not be used systemically for cancer therapy because of the side effects due to apoptosis induction in hepatocytes.
Although they could in principle be used systemically, proteolytic degradation and efficient peptide clearance pose as significant obstacles in the dynamic circulatory system.
Various drugs that are used systemically and/or topically to induce and maintain remission include aminosali cylates, glucocorticosteroids and immunomodulators [ 10– 16].
Ganciclovir has been used systemically, in the form of intravitreal injections and implants for CMV infections of the eye [7 9].
"If the corticosteroids had been used systemically (ie. injected or taken orally), the consecutive test results would have all been positive".
Colistin has been used systemically and by inhalation in P. aeruginosa-related CF therapy in Europe for decades.
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